Stronger effect / evidence




Weaker effect / evidence
Diisononyl phthalate (DINP-2 or DINP-3, mixture of isomers as manufactured)
CAS: 28553-12-0
How can this chemical affect my health?
Chronic (Long Term) EffectsData sources

Cancer – Can cause or increase the risk of cancer.

Endocrine Disruption – Can interfere with hormone communication between cells which controls metabolism, development, growth, reproduction and behavior (the endocrine system).

Birth Defects – Can cause harm to the developing child including birth defects, low birth weight and biological or behavioral problems that appear as the child grows.

Reproductive Harm – Can disrupt the male or female reproductive systems, changing sexual development, behavior or functions, decreasing fertility, or resulting in loss of the fetus during pregnancy.

Asthma Trigger – Can result in high sensitivity so that small quantities trigger asthma, nose or sinus inflammation or other allergic reactions in the respiratory system.
Data sources
Direct Hazard » Cancer
These sources refer directly to this chemical:
- CarcinogenCA EPA - Prop 65California Environmental Protection Agency (CA EPA)
Direct Hazard » Endocrine Disruption
These sources refer directly to this chemical:
- Category 2 - In vitro evidence of biological activity related to Endocrine DisruptionEU - Priority Endocrine DisruptorsEuropean Union / European Commission (EU EC)
- Endocrine DisruptionChemSec - SIN ListChemSec, The International Chemical Secretariat
- Potential Endocrine DisruptorTEDX - Potential Endocrine DisruptorsThe Endocrine Disruption Exchange (TEDX)
Direct Hazard » Birth Defects
These sources refer directly to this chemical:
- Some Evidence of Adverse Effects - Developmental ToxicityUS NIH - Reproductive & Developmental MonographsUS Department of Health & Human Services - National Institutes of Health (US NIH)
- Developmental toxicity - TSCA Criteria metUS EPA - PPT Chemical Action PlansUS Environmental Protection Agency (US EPA)
Direct Hazard » Reproductive Harm
These sources refer directly to this chemical:
- Limited Evidence of no Adverse Effects - Reproductive ToxicityUS NIH - Reproductive & Developmental MonographsUS Department of Health & Human Services - National Institutes of Health (US NIH)
- H361 - Suspected of damaging fertility or the unborn child [Toxic to reproduction - Category 2]GHS - JapanGovernment of Japan
- Repr. 2; H361 - Suspected of damaging fertility or the unborn child (modeled)DK-EPA - Danish Advisory ListDanish Environmental Protection Agency (DK-EPA)
Diisononyl Phthalate (dinp) Compounds » Reproductive Harm
These sources refer to a group of compounds containing this chemical:
- Reproductive effectsUS EPA - PPT Chemical Action PlansUS Environmental Protection Agency (US EPA)
Phthalates (orthophthalates) » Asthma Trigger
These sources refer to a group of compounds containing this chemical:
- Asthma - allergen, sensitizer - limited evidenceCHE - Toxicant DatabaseCollaborative on Health and the Environment (CHE)
- Asthma - irritant - limited evidenceCHE - Toxicant DatabaseCollaborative on Health and the Environment (CHE)
- Rhinitis – allergic - limited evidenceCHE - Toxicant DatabaseCollaborative on Health and the Environment (CHE)
Inherent HazardsData sources

Restricted List – This chemical is on a list from an authoritative body recommending that its use be avoided.
Data sources
Diisononyl Phthalate (dinp) Compounds » Restricted List
These sources refer to a group of compounds containing this chemical:
- EPA Chemical of Concern - Action Plan publishedUS EPA - PPT Chemical Action PlansUS Environmental Protection Agency (US EPA)
Direct Hazard » Restricted List
These sources refer directly to this chemical:
- TSCA Work Plan chemical - Action Plan in developmentUS EPA - PPT Chemical Action PlansUS Environmental Protection Agency (US EPA)
- Precautionary list of substances recommended for avoidanceP&W - Precautionary ListPerkins+Will (P+W)
- TSCA Work Plan chemical - ongoing chemical (risk) assessmentUS EPA - PPT Chemical Action PlansUS Environmental Protection Agency (US EPA)
- Chemicals of high concernSCHF - Hazardous 100Safer Chemicals, Healthy Families (SCHF)
- Priority Asthmagen to AvoidHBN - Priority AsthmagensHealthy Building Network (HBN)
- Candidate Chemical ListCA SCP - Candidate ChemicalsCalifornia Department of Toxic Substance Control (CA DTSC)
- Red List substances to avoid in Living Building Challenge V3 projectsLiving Building Challenge 3.0 - Red List of Materials & Chemicals (retiring December 31, 2024)International Living Future Institute (ILFI)
- Substances selected for RMOA or hazard assessmentEU - PACT-RMOA SubstancesEuropean Union / European Commission (EU EC)
- V3 2014 Substance of Concern ListBIFMA - e3/level Annex B list of chemicalsBusiness and Institutional Furniture Manufacturers Association (BIFMA)
- Bisphenols and PhthalatesGSPI - Six Classes of Problematic ChemicalsGreen Science Policy Institute (GSPI)
- Some SolventsGSPI - Six Classes of Problematic ChemicalsGreen Science Policy Institute (GSPI)
- Substances restricted under REACHEU - REACH Annex XVII non-CMRsEuropean Union / European Commission (EU EC)
- Chemicals of High ConcernMDH - Chemicals of High Concern and Priority ChemicalsMinnesota Department of Public Health
- Chemicals of High Concern to ChildrenWA DoE - Chemicals of High Concern to ChildrenWashington State Department of Ecology (WA DOE)
- Designated ChemicalCA DTSC - Biomonitoring California Chemical ListCalifornia Department of Toxic Substance Control (CA DTSC)
- CoHC List (non SVHC)CPA - Chemical FootprintClean Production Action (CPA)
- Children's ProductsC2C Certified v4 Product Standard Restricted Substances List (RSL) - Effective July 1, 2022Cradle to Cradle Products Innovation Institute (C2CPII)
- ZDHC - MRSL v1.1 for Textiles and Synthetic Leather ProcessingZDHC - MRSL v1.1Zero Discharge of Hazardous Waste Chemicals Programme
- ZDHC - MRSL v1.1 for Natural Leather ProcessingZDHC - MRSL v1.1Zero Discharge of Hazardous Waste Chemicals Programme
- Red List substances to avoid in Living Building Challenge V3.1 projectsLiving Building Challenge 3.1 - Red List of Materials & Chemicals (retiring December 31, 2024)International Living Future Institute (ILFI)
- Red List substances to avoid in Living Building Challenge V4.0 projectsLiving Building Challenge 4.0 - Red List of Materials & Chemicals - Effective April 1, 2023International Living Future Institute (ILFI)
- 2019 Substance of Concern ListBIFMA - e3/level Annex B list of chemicalsBusiness and Institutional Furniture Manufacturers Association (BIFMA)
- Tier 1 “Do Not Use Chemicals” for EveryoneCampaign for Safe Cosmetics’ Red List of Chemicals of ConcernCampaign for Safe Cosmetics
- Declarable and Reference Substance Lists (DSL and RSL)IEC 62474 - Material Declaration for Products of and for the Electrotechnical IndustryInternational Electrotechnical Commission
- Chemicals of High Concern to ChildrenVermont Chemicals of High Concern to ChildrenVermont Environmental Health Division
- Food Contact Chemicals Database Version 5.0Food Contact Chemicals Database (FCCdb)Food Packaging Forum
- Food Contact Chemicals of Concern List (FCCoCL) - TIER 1Food Contact Chemicals of Concern (FCCoCL)Food Packaging Forum
- PhthalatesAmerican Apparel and Footwear Association Restricted Substance List (AAFA RSL)American Apparel and Footwear Association
- Target Priority Chemicals List (TPCL)Target Corp - Target Priority Chemicals List (TPCL)Target Corporation
- ZDHC - MRSL v2.0ZDHC - MRSL v2.0Zero Discharge of Hazardous Waste Chemicals Programme
- EDF Key chemicals of concern in food packaging and food handling equipmentEDF Key chemicals of concern in food packaging and food handling equipmentEnvironmental Defense Fund
- FSAP Food Packaging Product Stewardship ConsiderationsFSAP Food Packaging Product Stewardship ConsiderationsFood Safety Alliance for Packaging (FSAP)
- FPF Priority Substance List from FCCdbFPF Priority Substance List from FCCdbFood Packaging Forum
- Ortho-PhthalatesGreenScreen Certified Standard for Food Service Ware RSLClean Production Action (CPA)
- Food Packaging Forum Priority Substances ListGreenScreen Certified Standard for Food Service Ware RSLClean Production Action (CPA)
- TSCA Chemical Substance Inventory - ActiveTSCA Chemical Substance Inventory (Active-Inactive)US Environmental Protection Agency (US EPA)
- PhthalatesAFIRM Packaging RSLThe Apparel and Footwear International RSL Management Group (AFIRM)
- Ortho-phthalates (Bronze List)GreenScreen Certified Standard for Furniture & Fabrics Bronze RSLClean Production Action (CPA)
- Ortho-phthalates (Silver-Gold)GreenScreen Certified Standard for Furniture & Fabrics Silver-Gold RSLClean Production Action (CPA)
- ZDHC Manufacturing Restricted Substances List (MRSL) Version 2.0GreenScreen Certified Standard for Furniture & Fabrics Silver-Gold RSLClean Production Action (CPA)
- ZDHC Manufacturing Restricted Substances List (MRSL) Version 2.0GreenScreen Certified Standard for Firefighting Foam RSLClean Production Action (CPA)
- ZDHC Manufacturing Restricted Substances List (MRSL) Version 2.0GreenScreen Certified Standard for Textile Chemicals RSLClean Production Action (CPA)
- GADSL Declarable Substances - Information is being collected for a non-regulatory purpose (D/FI)Global Automotive Declarable Substance List (GADSL)Global Automotive Stakeholder Group (GASG)
- Ortho-phthalates (Silver-Gold)GreenScreen Certified Standard for Medical Supplies & Devices Silver-Gold RSLClean Production Action (CPA)
- ZDHC Manufacturing Restricted Substances List (MRSL) Version 2.0GreenScreen Certified Standard for Medical Supplies & Devices Silver-Gold RSLClean Production Action (CPA)
- GreenScreen List Translator LT-1GreenScreen Certified Standard for Medical Supplies & Devices Silver-Gold RSLClean Production Action (CPA)
- Ortho-Phthalates (Bronze)GreenScreen Certified Standard for Medical Supplies & Devices Bronze RSLClean Production Action (CPA)
Phthalates (orthophthalates) » Restricted List
These sources refer to a group of compounds containing this chemical:
- Red List substance to avoid in Living Building Challenge V2.1 projectsLiving Building Challenge 2.1 - Red List of Materials & Chemicals (retired in 2014)International Living Future Institute (ILFI)
- Substance to avoid to fulfill LEED Pilot Credit 11USGBC - LEED Pilot CreditsUS Green Building Council (USGBC)
- Substance to avoid to fulfill LEED Pilot Credit 54 Option 2USGBC - LEED Pilot CreditsUS Green Building Council (USGBC)
- Priority ChemicalsME DEP - Chemicals of High Concern and Priority ChemicalsMaine Department of Environmental Protection
- Prospective Red List substances to avoid in Living Building Challenge projectsLiving Building Challenge 3.0 - Red List of Materials & Chemicals (retiring December 31, 2024)International Living Future Institute (ILFI)
- Prohibited ChemicalsCredo Beauty's Restricted Substance ListCredo
Ortho-phthalates - Biomonitoring Ca » Restricted List
These sources refer to a group of compounds containing this chemical:
- Priority ChemicalCA DTSC - Biomonitoring California Chemical ListCalifornia Department of Toxic Substance Control (CA DTSC)
[105009-97-0] Diisononyl Phthalate (dinp-2 Or Dinp-3, Mixture Of Isomers As Manufactured) (primary Casrn Is 28553-12-0) » Restricted List
These sources refer to a group of compounds containing this chemical:
- Priority for Inclusion in the Living Building Challenge Red ListLiving Building Challenge 4.0 - Red List of Materials & Chemicals - Effective April 1, 2023International Living Future Institute (ILFI)
How does this chemical impact the environment?Data sources

Bioaccumulative – Accumulates in organisms, concentrating as it moves up the food chain.

Persistent – Does not break down readily from natural processes.
Data sources
Direct Hazard » Bioaccumulative
These sources refer directly to this chemical:
- Low bioaccumulation potential - TSCA Criteria metUS EPA - PPT Chemical Action PlansUS Environmental Protection Agency (US EPA)
Direct Hazard » Persistent
These sources refer directly to this chemical:
- Low environmental persistence - TSCA Criteria metUS EPA - PPT Chemical Action PlansUS Environmental Protection Agency (US EPA)
What safer alternatives are available for this chemical?
Find case studies related to substitutions for this chemical in SubsPORT, the substitution support portal.