Stronger effect / evidence
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Weaker effect / evidence

Diisononyl phthalate (DINP-2 or DINP-3, mixture of isomers as manufactured)

CAS: 28553-12-0

How can this chemical affect my health?

Chronic (Long Term) EffectsData sources

Cancer, priority red
Cancer – Can cause or increase the risk of cancer.
Endocrine Disruption, priority orange
Endocrine Disruption – Can interfere with hormone communication between cells which controls metabolism, development, growth, reproduction and behavior (the endocrine system).
Birth Defects, priority orange
Birth Defects – Can cause harm to the developing child including birth defects, low birth weight and biological or behavioral problems that appear as the child grows.
Reproductive Harm, priority yellow
Reproductive Harm – Can disrupt the male or female reproductive systems, changing sexual development, behavior or functions, decreasing fertility, or resulting in loss of the fetus during pregnancy.
Asthma Trigger, priority yellow
Asthma Trigger – Can result in high sensitivity so that small quantities trigger asthma, nose or sinus inflammation or other allergic reactions in the respiratory system.

Data sources

Direct Hazard » Cancer

These sources refer directly to this chemical:

  • Carcinogen
    CA EPA - Prop 65
    California Environmental Protection Agency (CA EPA)

Direct Hazard » Endocrine Disruption

These sources refer directly to this chemical:

  • Category 2 - In vitro evidence of biological activity related to Endocrine Disruption
    EU - Priority Endocrine Disruptors
    European Union / European Commission (EU EC)
  • Endocrine Disruption
    ChemSec - SIN List
    ChemSec, The International Chemical Secretariat
  • Potential Endocrine Disruptor
    TEDX - Potential Endocrine Disruptors
    The Endocrine Disruption Exchange (TEDX)

Direct Hazard » Birth Defects

These sources refer directly to this chemical:

  • Some Evidence of Adverse Effects - Developmental Toxicity
    US NIH - Reproductive & Developmental Monographs
    US Department of Health & Human Services - National Institutes of Health (US NIH)
  • Developmental toxicity - TSCA Criteria met
    US EPA - PPT Chemical Action Plans
    US Environmental Protection Agency (US EPA)

Direct Hazard » Reproductive Harm

These sources refer directly to this chemical:

  • Limited Evidence of no Adverse Effects - Reproductive Toxicity
    US NIH - Reproductive & Developmental Monographs
    US Department of Health & Human Services - National Institutes of Health (US NIH)
  • H361 - Suspected of damaging fertility or the unborn child [Toxic to reproduction - Category 2]
    GHS - Japan
    Government of Japan
  • Repr. 2; H361 - Suspected of damaging fertility or the unborn child (modeled)
    DK-EPA - Danish Advisory List
    Danish Environmental Protection Agency (DK-EPA)

Diisononyl Phthalate (dinp) Compounds » Reproductive Harm

These sources refer to a group of compounds containing this chemical:

  • Reproductive effects
    US EPA - PPT Chemical Action Plans
    US Environmental Protection Agency (US EPA)

Phthalates (orthophthalates) » Asthma Trigger

These sources refer to a group of compounds containing this chemical:

  • Asthma - allergen, sensitizer - limited evidence
    CHE - Toxicant Database
    Collaborative on Health and the Environment (CHE)
  • Asthma - irritant - limited evidence
    CHE - Toxicant Database
    Collaborative on Health and the Environment (CHE)
  • Rhinitis – allergic - limited evidence
    CHE - Toxicant Database
    Collaborative on Health and the Environment (CHE)
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Inherent HazardsData sources

Restricted List, priority gray
Restricted List – This chemical is on a list from an authoritative body recommending that its use be avoided.

Data sources

Diisononyl Phthalate (dinp) Compounds » Restricted List

These sources refer to a group of compounds containing this chemical:

  • EPA Chemical of Concern - Action Plan published
    US EPA - PPT Chemical Action Plans
    US Environmental Protection Agency (US EPA)

Direct Hazard » Restricted List

These sources refer directly to this chemical:

  • TSCA Work Plan chemical - Action Plan in development
    US EPA - PPT Chemical Action Plans
    US Environmental Protection Agency (US EPA)
  • Precautionary list of substances recommended for avoidance
    P&W - Precautionary List
    Perkins+Will (P+W)
  • TSCA Work Plan chemical - ongoing chemical (risk) assessment
    US EPA - PPT Chemical Action Plans
    US Environmental Protection Agency (US EPA)
  • Chemicals of high concern
    SCHF - Hazardous 100
    Safer Chemicals, Healthy Families (SCHF)
  • Priority Asthmagen to Avoid
    HBN - Priority Asthmagens
    Healthy Building Network (HBN)
  • Candidate Chemical List
    CA SCP - Candidate Chemicals
    California Department of Toxic Substance Control (CA DTSC)
  • Red List substances to avoid in Living Building Challenge V3 projects
    Living Building Challenge 3.0 - Red List of Materials & Chemicals (retiring December 31, 2024)
    International Living Future Institute (ILFI)
  • Substances selected for RMOA or hazard assessment
    EU - PACT-RMOA Substances
    European Union / European Commission (EU EC)
  • V3 2014 Substance of Concern List
    BIFMA - e3/level Annex B list of chemicals
    Business and Institutional Furniture Manufacturers Association (BIFMA)
  • Bisphenols and Phthalates
    GSPI - Six Classes of Problematic Chemicals
    Green Science Policy Institute (GSPI)
  • Some Solvents
    GSPI - Six Classes of Problematic Chemicals
    Green Science Policy Institute (GSPI)
  • Substances restricted under REACH
    EU - REACH Annex XVII non-CMRs
    European Union / European Commission (EU EC)
  • Chemicals of High Concern
    MDH - Chemicals of High Concern and Priority Chemicals
    Minnesota Department of Public Health
  • Chemicals of High Concern to Children
    WA DoE - Chemicals of High Concern to Children
    Washington State Department of Ecology (WA DOE)
  • Designated Chemical
    CA DTSC - Biomonitoring California Chemical List
    California Department of Toxic Substance Control (CA DTSC)
  • CoHC List (non SVHC)
    CPA - Chemical Footprint
    Clean Production Action (CPA)
  • Children's Products
    C2C Certified v4 Product Standard Restricted Substances List (RSL) - Effective July 1, 2022
    Cradle to Cradle Products Innovation Institute (C2CPII)
  • ZDHC - MRSL v1.1 for Textiles and Synthetic Leather Processing
    ZDHC - MRSL v1.1
    Zero Discharge of Hazardous Waste Chemicals Programme
  • ZDHC - MRSL v1.1 for Natural Leather Processing
    ZDHC - MRSL v1.1
    Zero Discharge of Hazardous Waste Chemicals Programme
  • Red List substances to avoid in Living Building Challenge V3.1 projects
    Living Building Challenge 3.1 - Red List of Materials & Chemicals (retiring December 31, 2024)
    International Living Future Institute (ILFI)
  • Red List substances to avoid in Living Building Challenge V4.0 projects
    Living Building Challenge 4.0 - Red List of Materials & Chemicals - Effective April 1, 2023
    International Living Future Institute (ILFI)
  • 2019 Substance of Concern List
    BIFMA - e3/level Annex B list of chemicals
    Business and Institutional Furniture Manufacturers Association (BIFMA)
  • Tier 1 “Do Not Use Chemicals” for Everyone
    Campaign for Safe Cosmetics’ Red List of Chemicals of Concern
    Campaign for Safe Cosmetics
  • Declarable and Reference Substance Lists (DSL and RSL)
    IEC 62474 - Material Declaration for Products of and for the Electrotechnical Industry
    International Electrotechnical Commission
  • Chemicals of High Concern to Children
    Vermont Chemicals of High Concern to Children
    Vermont Environmental Health Division
  • Food Contact Chemicals Database Version 5.0
    Food Contact Chemicals Database (FCCdb)
    Food Packaging Forum
  • Food Contact Chemicals of Concern List (FCCoCL) - TIER 1
    Food Contact Chemicals of Concern (FCCoCL)
    Food Packaging Forum
  • Phthalates
    American Apparel and Footwear Association Restricted Substance List (AAFA RSL)
    American Apparel and Footwear Association
  • Target Priority Chemicals List (TPCL)
    Target Corp - Target Priority Chemicals List (TPCL)
    Target Corporation
  • ZDHC - MRSL v2.0
    ZDHC - MRSL v2.0
    Zero Discharge of Hazardous Waste Chemicals Programme
  • EDF Key chemicals of concern in food packaging and food handling equipment
    EDF Key chemicals of concern in food packaging and food handling equipment
    Environmental Defense Fund
  • FSAP Food Packaging Product Stewardship Considerations
    FSAP Food Packaging Product Stewardship Considerations
    Food Safety Alliance for Packaging (FSAP)
  • FPF Priority Substance List from FCCdb
    FPF Priority Substance List from FCCdb
    Food Packaging Forum
  • Ortho-Phthalates
    GreenScreen Certified Standard for Food Service Ware RSL
    Clean Production Action (CPA)
  • Food Packaging Forum Priority Substances List
    GreenScreen Certified Standard for Food Service Ware RSL
    Clean Production Action (CPA)
  • TSCA Chemical Substance Inventory - Active
    TSCA Chemical Substance Inventory (Active-Inactive)
    US Environmental Protection Agency (US EPA)
  • Phthalates
    AFIRM Packaging RSL
    The Apparel and Footwear International RSL Management Group (AFIRM)
  • Ortho-phthalates (Bronze List)
    GreenScreen Certified Standard for Furniture & Fabrics Bronze RSL
    Clean Production Action (CPA)
  • Ortho-phthalates (Silver-Gold)
    GreenScreen Certified Standard for Furniture & Fabrics Silver-Gold RSL
    Clean Production Action (CPA)
  • ZDHC Manufacturing Restricted Substances List (MRSL) Version 2.0
    GreenScreen Certified Standard for Furniture & Fabrics Silver-Gold RSL
    Clean Production Action (CPA)
  • ZDHC Manufacturing Restricted Substances List (MRSL) Version 2.0
    GreenScreen Certified Standard for Firefighting Foam RSL
    Clean Production Action (CPA)
  • ZDHC Manufacturing Restricted Substances List (MRSL) Version 2.0
    GreenScreen Certified Standard for Textile Chemicals RSL
    Clean Production Action (CPA)
  • GADSL Declarable Substances - Information is being collected for a non-regulatory purpose (D/FI)
    Global Automotive Declarable Substance List (GADSL)
    Global Automotive Stakeholder Group (GASG)
  • Ortho-phthalates (Silver-Gold)
    GreenScreen Certified Standard for Medical Supplies & Devices Silver-Gold RSL
    Clean Production Action (CPA)
  • ZDHC Manufacturing Restricted Substances List (MRSL) Version 2.0
    GreenScreen Certified Standard for Medical Supplies & Devices Silver-Gold RSL
    Clean Production Action (CPA)
  • GreenScreen List Translator LT-1
    GreenScreen Certified Standard for Medical Supplies & Devices Silver-Gold RSL
    Clean Production Action (CPA)
  • Ortho-Phthalates (Bronze)
    GreenScreen Certified Standard for Medical Supplies & Devices Bronze RSL
    Clean Production Action (CPA)

Phthalates (orthophthalates) » Restricted List

These sources refer to a group of compounds containing this chemical:

  • Red List substance to avoid in Living Building Challenge V2.1 projects
    Living Building Challenge 2.1 - Red List of Materials & Chemicals (retired in 2014)
    International Living Future Institute (ILFI)
  • Substance to avoid to fulfill LEED Pilot Credit 11
    USGBC - LEED Pilot Credits
    US Green Building Council (USGBC)
  • Substance to avoid to fulfill LEED Pilot Credit 54 Option 2
    USGBC - LEED Pilot Credits
    US Green Building Council (USGBC)
  • Priority Chemicals
    ME DEP - Chemicals of High Concern and Priority Chemicals
    Maine Department of Environmental Protection
  • Prospective Red List substances to avoid in Living Building Challenge projects
    Living Building Challenge 3.0 - Red List of Materials & Chemicals (retiring December 31, 2024)
    International Living Future Institute (ILFI)
  • Prohibited Chemicals
    Credo Beauty's Restricted Substance List
    Credo

Ortho-phthalates - Biomonitoring Ca » Restricted List

These sources refer to a group of compounds containing this chemical:

  • Priority Chemical
    CA DTSC - Biomonitoring California Chemical List
    California Department of Toxic Substance Control (CA DTSC)

[105009-97-0] Diisononyl Phthalate (dinp-2 Or Dinp-3, Mixture Of Isomers As Manufactured) (primary Casrn Is 28553-12-0) » Restricted List

These sources refer to a group of compounds containing this chemical:

  • Priority for Inclusion in the Living Building Challenge Red List
    Living Building Challenge 4.0 - Red List of Materials & Chemicals - Effective April 1, 2023
    International Living Future Institute (ILFI)
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How does this chemical impact the environment?Data sources

Bioaccumulative , priority gray
Bioaccumulative – Accumulates in organisms, concentrating as it moves up the food chain.
Persistent, priority gray
Persistent – Does not break down readily from natural processes.

Data sources

Direct Hazard » Bioaccumulative

These sources refer directly to this chemical:

  • Low bioaccumulation potential - TSCA Criteria met
    US EPA - PPT Chemical Action Plans
    US Environmental Protection Agency (US EPA)

Direct Hazard » Persistent

These sources refer directly to this chemical:

  • Low environmental persistence - TSCA Criteria met
    US EPA - PPT Chemical Action Plans
    US Environmental Protection Agency (US EPA)
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What safer alternatives are available for this chemical?

Find case studies related to substitutions for this chemical in SubsPORT, the substitution support portal.