Stronger effect / evidence




Weaker effect / evidence
Bisphenol A
CAS: 80-05-7
How can this chemical affect my health?
Acute (Short Term) EffectsData sources

Irritates the Eyes – Can cause irritation or serious damage to the eye.
Data sources
Direct Hazard » Irritates the Eyes
These sources refer directly to this chemical:
- H318 - Causes serious eye damage [Serious eye damage/eye irritation - Category 1]EU - GHS (H-Statements) Annex 6 Table 3-1European Union / European Commission (EU EC)
- Serious eye damage category 1GHS - New ZealandNew Zealand Environmental Protection Authority (NZ EPA)
- H318 - Causes serious eye damage [Serious eye damage / eye irritation - Category 1]GHS - JapanGovernment of Japan
- H318 - Causes serious eye damage [Serious eye damage/eye irritation - Category 1]GHS - AustraliaSafe Work Australia
- H318 - Causes serious eye damage (unverified) [Serious eye damage/eye irritation - Category 1]EU - Manufacturer REACH hazard submissionsEuropean Union / European Commission (EU EC)
Chronic (Long Term) EffectsData sources

Birth Defects – Can cause harm to the developing child including birth defects, low birth weight and biological or behavioral problems that appear as the child grows.

Endocrine Disruption – Can interfere with hormone communication between cells which controls metabolism, development, growth, reproduction and behavior (the endocrine system).

Reproductive Harm – Can disrupt the male or female reproductive systems, changing sexual development, behavior or functions, decreasing fertility, or resulting in loss of the fetus during pregnancy.

Sensitizes the Skin – Can lead to allergic reactions on the skin.

Other Health Effects – Can cause serious damage on contact or ingestion.
Data sources
Direct Hazard » Birth Defects
These sources refer directly to this chemical:
- Developmental toxicityCA EPA - Prop 65California Environmental Protection Agency (CA EPA)
- Clear Evidence of Adverse Effects - Developmental ToxicityUS NIH - Reproductive & Developmental MonographsUS Department of Health & Human Services - National Institutes of Health (US NIH)
- Pregnancy Risk Group CMAKMAK Commission of Germany (Deutsche Forschungsgemeinschaft)
- H361 - Suspected of damaging fertility or the unborn child (unverified) [Reproductive toxicity - Category 2]EU - Manufacturer REACH hazard submissionsEuropean Union / European Commission (EU EC)
Direct Hazard » Endocrine Disruption
These sources refer directly to this chemical:
- Category 1 - In vivo evidence of Endocrine Disruption ActivityEU - Priority Endocrine DisruptorsEuropean Union / European Commission (EU EC)
- Endocrine Disruptor - Substance of Possible ConcernOSPAR - Priority PBTs & EDs & equivalent concernOslo-Paris Convention Commission (OSPAR)
- Endocrine DisruptionChemSec - SIN ListChemSec, The International Chemical Secretariat
- Potential Endocrine DisruptorTEDX - Potential Endocrine DisruptorsThe Endocrine Disruption Exchange (TEDX)
- Equivalent Concern - Candidate List: endocrine disrupting properties cause probable serious effects to the environment or human healthEU - SVHC ListEuropean Union / European Commission (EU EC)
- ECHA Endocrine disruptor assessment listECHA Endocrine DisruptorsEuropean Union / European Commission (EU EC)
- ED List I - Substances identified as endocrine disruptors at EU levelEndocrine Disruptor Lists (Danish EPA)Danish Environmental Protection Agency (DK-EPA)
Direct Hazard » Reproductive Harm
These sources refer directly to this chemical:
- Reproductive Toxicity - FemaleCA EPA - Prop 65California Environmental Protection Agency (CA EPA)
- Toxic to reproduction - Candidate listEU - SVHC ListEuropean Union / European Commission (EU EC)
- Some Evidence of Adverse Effects - Reproductive ToxicityUS NIH - Reproductive & Developmental MonographsUS Department of Health & Human Services - National Institutes of Health (US NIH)
- H360F - May damage fertility [Reproductive toxicity - Category 1A or 1B]EU - GHS (H-Statements) Annex 6 Table 3-1European Union / European Commission (EU EC)
- Reproductive toxicants: Category 1BEU - REACH Annex XVII CMRsEuropean Union / European Commission (EU EC)
- Reproductive toxicity category 2GHS - New ZealandNew Zealand Environmental Protection Authority (NZ EPA)
- H360 - May damage fertility or the unborn child [Toxic to reproduction - Category 1B]GHS - JapanGovernment of Japan
- Reproductive toxicity - TSCA Criteria metUS EPA - PPT Chemical Action PlansUS Environmental Protection Agency (US EPA)
- Reproductive Toxicity - Category 1BEU - Annex VI CMRsEuropean Union / European Commission (EU EC)
- H361f - Suspected of damaging fertility [Reproductive toxicity - Category 2]GHS - AustraliaSafe Work Australia
- H360 - Suspected of / May damage fertility and/or the unborn child (unverified) [Reproductive toxicity - Category 1A or 1B]EU - Manufacturer REACH hazard submissionsEuropean Union / European Commission (EU EC)
Direct Hazard » Sensitizes the Skin
These sources refer directly to this chemical:
- H317 - May cause an allergic skin reaction [Skin sensitization - Category 1]EU - GHS (H-Statements) Annex 6 Table 3-1European Union / European Commission (EU EC)
- Sensitizing Substance SP - Danger of photocontact sensitizationMAKMAK Commission of Germany (Deutsche Forschungsgemeinschaft)
- Skin sensitisation category 1GHS - New ZealandNew Zealand Environmental Protection Authority (NZ EPA)
- H317 - May cause an allergic skin reaction [Skin sensitizer - Category 1]GHS - JapanGovernment of Japan
- H317 - May cause an allergic skin reaction [Skin sensitization - Category 1]GHS - AustraliaSafe Work Australia
- H317 - May cause an allergic skin reaction (unverified) [Skin sensitization - Category 1]EU - Manufacturer REACH hazard submissionsEuropean Union / European Commission (EU EC)
Direct Hazard » Other Health Effects
These sources refer directly to this chemical:
- H335 - May cause respiratory irritation [Specific target organ toxicity - single exposure; Respiratory tract irritation - Category 3]EU - GHS (H-Statements) Annex 6 Table 3-1European Union / European Commission (EU EC)
- H373 - May cause damage to organs through prolonged or repeated exposure [Specific target organs/systemic toxicity following repeated exposure - Category 2]GHS - JapanGovernment of Japan
- H370 - Causes damage to organs [Specific target organs/systemic toxicity following single exposure - Category 1]GHS - JapanGovernment of Japan
- H335 - May cause respiratory irritation [Specific target organ toxicity - single exposure; Respiratory tract irritation - Category 3]GHS - AustraliaSafe Work Australia
- H335 - May cause respiratory irritation (unverified) [Specific target organ toxicity - single exposure; Respiratory tract irritation - Category 3]EU - Manufacturer REACH hazard submissionsEuropean Union / European Commission (EU EC)
- H370 - Causes damage to organs (unverified) [Specific target organ toxicity - single exposure - Category 1]EU - Manufacturer REACH hazard submissionsEuropean Union / European Commission (EU EC)
Inherent HazardsData sources

Restricted List – This chemical is on a list from an authoritative body recommending that its use be avoided.
Data sources
Direct Hazard » Restricted List
These sources refer directly to this chemical:
- EPA Chemical of Concern - Action Plan publishedUS EPA - PPT Chemical Action PlansUS Environmental Protection Agency (US EPA)
- TSCA Work Plan chemical - Action Plan in developmentUS EPA - PPT Chemical Action PlansUS Environmental Protection Agency (US EPA)
- Precautionary list of substances recommended for avoidanceP&W - Precautionary ListPerkins+Will (P+W)
- Chemicals of high concernSCHF - Hazardous 100Safer Chemicals, Healthy Families (SCHF)
- Candidate Chemical ListCA SCP - Candidate ChemicalsCalifornia Department of Toxic Substance Control (CA DTSC)
- Red List substances to avoid in Living Building Challenge V3 projectsLiving Building Challenge 3.0 - Red List of Materials & Chemicals (retiring December 31, 2024)International Living Future Institute (ILFI)
- Substances selected for RMOA or hazard assessmentEU - PACT-RMOA SubstancesEuropean Union / European Commission (EU EC)
- V3 2014 Substance of Concern ListBIFMA - e3/level Annex B list of chemicalsBusiness and Institutional Furniture Manufacturers Association (BIFMA)
- Bisphenols and PhthalatesGSPI - Six Classes of Problematic ChemicalsGreen Science Policy Institute (GSPI)
- Substances restricted under REACHEU - REACH Annex XVII non-CMRsEuropean Union / European Commission (EU EC)
- Ingredients that are Prohibited for Use in Cosmetic ProductsHealth Canada - Cosmetic Ingredient HotlistHealth Canada
- Priority ChemicalsME DEP - Chemicals of High Concern and Priority ChemicalsMaine Department of Environmental Protection
- Chemicals of High ConcernMDH - Chemicals of High Concern and Priority ChemicalsMinnesota Department of Public Health
- Priority ChemicalsMDH - Chemicals of High Concern and Priority ChemicalsMinnesota Department of Public Health
- Chemicals of High Concern to ChildrenWA DoE - Chemicals of High Concern to ChildrenWashington State Department of Ecology (WA DOE)
- Annex II - Prohibited SubstancesEU - Cosmetics RegulationEuropean Union / European Commission (EU EC)
- Designated ChemicalCA DTSC - Biomonitoring California Chemical ListCalifornia Department of Toxic Substance Control (CA DTSC)
- CoHC List (non SVHC)CPA - Chemical FootprintClean Production Action (CPA)
- Biological and Environmentally Released MaterialsC2C Certified v4 Product Standard Restricted Substances List (RSL) - Effective July 1, 2022Cradle to Cradle Products Innovation Institute (C2CPII)
- Children's ProductsC2C Certified v4 Product Standard Restricted Substances List (RSL) - Effective July 1, 2022Cradle to Cradle Products Innovation Institute (C2CPII)
- Formulated Consumer ProductsC2C Certified v4 Product Standard Restricted Substances List (RSL) - Effective July 1, 2022Cradle to Cradle Products Innovation Institute (C2CPII)
- Red List substances to avoid in Living Building Challenge V3.1 projectsLiving Building Challenge 3.1 - Red List of Materials & Chemicals (retiring December 31, 2024)International Living Future Institute (ILFI)
- Red List substances to avoid in Living Building Challenge V4.0 projectsLiving Building Challenge 4.0 - Red List of Materials & Chemicals - Effective April 1, 2023International Living Future Institute (ILFI)
- 2019 Substance of Concern ListBIFMA - e3/level Annex B list of chemicalsBusiness and Institutional Furniture Manufacturers Association (BIFMA)
- Declarable and Reference Substance Lists (DSL and RSL)IEC 62474 - Material Declaration for Products of and for the Electrotechnical IndustryInternational Electrotechnical Commission
- Chemicals of High Concern to ChildrenVermont Chemicals of High Concern to ChildrenVermont Environmental Health Division
- Reportable ChemicalsMA Toxics Use Reduction Act (TURA) listed substancesMassachusetts Department of Environmental Protection
- Cosmetics & Personal Care ProductsC2C Certified v4 Product Standard Restricted Substances List (RSL) - Effective July 1, 2022Cradle to Cradle Products Innovation Institute (C2CPII)
- Food Contact Chemicals Database Version 5.0Food Contact Chemicals Database (FCCdb)Food Packaging Forum
- Food Contact Chemicals of Concern List (FCCoCL) - TIER 1Food Contact Chemicals of Concern (FCCoCL)Food Packaging Forum
- Substances of Very High Concern (RIVM ZZS)Substances of Very High Concern (RIVM ZZS)The National Institute for Public Health and the Environment (RIVM)
- Substances Restricted in ToysThe Toy Safety DirectiveEuropean Union / European Commission (EU EC)
- Target Priority Chemicals List (TPCL)Target Corp - Target Priority Chemicals List (TPCL)Target Corporation
- ZDHC - MRSL v2.0ZDHC - MRSL v2.0Zero Discharge of Hazardous Waste Chemicals Programme
- EDF Key chemicals of concern in food packaging and food handling equipmentEDF Key chemicals of concern in food packaging and food handling equipmentEnvironmental Defense Fund
- FSAP Food Packaging Product Stewardship ConsiderationsFSAP Food Packaging Product Stewardship ConsiderationsFood Safety Alliance for Packaging (FSAP)
- FPF Priority Substance List from FCCdbFPF Priority Substance List from FCCdbFood Packaging Forum
- BisphenolsGreenScreen Certified Standard for Food Service Ware RSLClean Production Action (CPA)
- Food Packaging Forum Priority Substances ListGreenScreen Certified Standard for Food Service Ware RSLClean Production Action (CPA)
- TSCA Chemical Substance Inventory - ActiveTSCA Chemical Substance Inventory (Active-Inactive)US Environmental Protection Agency (US EPA)
- BisphenolsAFIRM Packaging RSLThe Apparel and Footwear International RSL Management Group (AFIRM)
- Bisphenols (Bronze List)GreenScreen Certified Standard for Furniture & Fabrics Bronze RSLClean Production Action (CPA)
- Bisphenols (Silver-Gold)GreenScreen Certified Standard for Furniture & Fabrics Silver-Gold RSLClean Production Action (CPA)
- GADSL Declarable Substances - Reporting is required by a regulation (D/LR)Global Automotive Declarable Substance List (GADSL)Global Automotive Stakeholder Group (GASG)
- Bisphenols (Silver-Gold)GreenScreen Certified Standard for Medical Supplies & Devices Silver-Gold RSLClean Production Action (CPA)
- GreenScreen List Translator LT-1GreenScreen Certified Standard for Medical Supplies & Devices Silver-Gold RSLClean Production Action (CPA)
- Bisphenols (Bronze List)GreenScreen Certified Standard for Medical Supplies & Devices Bronze RSLClean Production Action (CPA)
How does this chemical impact the environment?Data sources

Immediate Harm to Aquatic Ecosystems – A single exposure may result in severe biological harm or death to fish or other aquatic organisms.

Long-Term Harm to Aquatic Ecosystems – Long term exposure may result in irreversible harm to fish or other aquatic organisms.

Bioaccumulative – Accumulates in organisms, concentrating as it moves up the food chain.

Persistent – Does not break down readily from natural processes.
Data sources
Direct Hazard » Immediate Harm to Aquatic Ecosystems
These sources refer directly to this chemical:
- H400 - Very toxic to aquatic life [Hazardous to the aquatic environment (acute) - Category 1]EU - GHS (H-Statements) Annex 6 Table 3-1European Union / European Commission (EU EC)
- H401 - Toxic to aquatic life [Hazardous to the aquatic environment (acute) - Category 2]GHS - JapanGovernment of Japan
- H400 - Very toxic to aquatic life (unverified) [Hazardous to the aquatic environment (acute) - Category 1]EU - Manufacturer REACH hazard submissionsEuropean Union / European Commission (EU EC)
- Hazardous to the aquatic environment - acute category 1GHS - New ZealandNew Zealand Environmental Protection Authority (NZ EPA)
Direct Hazard » Long-Term Harm to Aquatic Ecosystems
These sources refer directly to this chemical:
- H410 - Very toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment (chronic) - Category 1]EU - GHS (H-Statements) Annex 6 Table 3-1European Union / European Commission (EU EC)
- H411 - Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment (chronic) - Category 2]GHS - JapanGovernment of Japan
- H412 - Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment (chronic) - Category 3]GHS - JapanGovernment of Japan
- H412 - Harmful to aquatic life with long lasting effects (unverified) [Hazardous to the aquatic environment (chronic) - Category 3]EU - Manufacturer REACH hazard submissionsEuropean Union / European Commission (EU EC)
- H410 - Very toxic to aquatic life with long lasting effects (unverified) [Hazardous to the aquatic environment (chronic) - Category 1]EU - Manufacturer REACH hazard submissionsEuropean Union / European Commission (EU EC)
- H411 - Toxic to aquatic life with long lasting effects (unverified) [Hazardous to the aquatic environment (chronic) - Category 2]EU - Manufacturer REACH hazard submissionsEuropean Union / European Commission (EU EC)
Direct Hazard » Bioaccumulative
These sources refer directly to this chemical:
- Low bioaccumulation potential - TSCA Criteria metUS EPA - PPT Chemical Action PlansUS Environmental Protection Agency (US EPA)
Direct Hazard » Persistent
These sources refer directly to this chemical:
- Low environmental persistence - TSCA Criteria metUS EPA - PPT Chemical Action PlansUS Environmental Protection Agency (US EPA)
What safer alternatives are available for this chemical?
Find case studies related to substitutions for this chemical in SubsPORT, the substitution support portal.
How am I likely to be exposed to this chemical?

Skin contact

Eye contact

Inhalation
How can I protect myself from exposure to this chemical in the workplace?

Handle with gloves

Safety eyeware

Protective clothing

Respirator