Bisphenol A

CAS: 80-05-7

How can this chemical affect my health?

Acute (Short Term) EffectsData sources

Irritates the Eyes – Can cause irritation or serious damage to the eye.

Toxic To Humans & Animals, priority yellow

Toxic to Humans & Animals – Can be fatal on contact, ingestion or inhalation for humans and other mammals.

Chronic (Long Term) EffectsData sources

Birth Defects – Can cause harm to the developing child including birth defects, low birth weight and biological or behavioral problems that appear as the child grows.

Endocrine Disruption – Can interfere with hormone communication between cells which controls metabolism, development, growth, reproduction and behavior (the endocrine system).

Reproductive Harm – Can disrupt the male or female reproductive systems, changing sexual development, behavior or functions, decreasing fertility, or resulting in loss of the fetus during pregnancy.

Sensitizes the Skin – Can lead to allergic reactions on the skin.

Other Health Effects – Can cause serious damage on contact or ingestion.

Data sources

Direct Hazard » Birth Defects

These sources refer directly to this chemical:

Developmental toxicity
CA EPA - Prop 65
California Environmental Protection Agency (CA EPA)
Clear Evidence of Adverse Effects - Developmental Toxicity
US NIH - Reproductive & Developmental Monographs
US Department of Health & Human Services - National Institutes of Health (US NIH)
Pregnancy Risk Group C
MAK
MAK Commission of Germany (Deutsche Forschungsgemeinschaft)
H361 - Suspected of damaging fertility or the unborn child (unverified) [Reproductive toxicity - Category 2]
EU - Manufacturer REACH hazard submissions
European Union / European Commission (EU EC)

Direct Hazard » Endocrine Disruption

These sources refer directly to this chemical:

Category 1 - In vivo evidence of Endocrine Disruption Activity
EU - Priority Endocrine Disruptors
European Union / European Commission (EU EC)
Endocrine Disruptor - Substance of Possible Concern
OSPAR - Priority PBTs & EDs & equivalent concern
Oslo-Paris Convention Commission (OSPAR)
Endocrine Disruption
ChemSec - SIN List
ChemSec, The International Chemical Secretariat
Potential Endocrine Disruptor
TEDX - Potential Endocrine Disruptors
The Endocrine Disruption Exchange (TEDX)
Equivalent Concern - Prioritization List: endocrine disrupting properties cause probable serious effects to the environment or human health
EU - SVHC List
European Union / European Commission (EU EC)
Equivalent Concern - Candidate List: endocrine disrupting properties cause probable serious effects to the environment or human health
EU - SVHC List
European Union / European Commission (EU EC)
ECHA Endocrine disruptor assessment list
ECHA Endocrine Disruptors
European Union / European Commission (EU EC)
ED List I - Substances identified as endocrine disruptors at EU level
Endocrine Disruptor Lists (Danish EPA)
Danish Environmental Protection Agency (DK-EPA)

Direct Hazard » Reproductive Harm

These sources refer directly to this chemical:

Reproductive Toxicity - Female
CA EPA - Prop 65
California Environmental Protection Agency (CA EPA)
Toxic to reproduction - Candidate list
EU - SVHC List
European Union / European Commission (EU EC)
Toxic to reproduction - Prioritized for listing
EU - SVHC List
European Union / European Commission (EU EC)
Some Evidence of Adverse Effects - Reproductive Toxicity
US NIH - Reproductive & Developmental Monographs
US Department of Health & Human Services - National Institutes of Health (US NIH)
H360F - May damage fertility [Reproductive toxicity - Category 1A or 1B]
EU - GHS (H-Statements) Annex 6 Table 3-1
European Union / European Commission (EU EC)
Reproductive toxicants: Category 1B
EU - REACH Annex XVII CMRs
European Union / European Commission (EU EC)
Reproductive toxicity category 2
GHS - New Zealand
Te Mana Rauhī Taiao (New Zealand EPA)
H360 - May damage fertility or the unborn child [Toxic to reproduction - Category 1B]
GHS - Japan
Government of Japan
Reproductive toxicity - TSCA Criteria met
US EPA - PPT Chemical Action Plans
US Environmental Protection Agency (US EPA)
Reproductive Toxicity - Category 1B
EU - Annex VI CMRs
European Union / European Commission (EU EC)
H361f - Suspected of damaging fertility [Reproductive toxicity - Category 2]
GHS - Australia
Safe Work Australia
H360 - Suspected of / May damage fertility and/or the unborn child (unverified) [Reproductive toxicity - Category 1A or 1B]
EU - Manufacturer REACH hazard submissions
European Union / European Commission (EU EC)

Direct Hazard » Sensitizes the Skin

These sources refer directly to this chemical:

H317 - May cause an allergic skin reaction [Skin sensitization - Category 1]
EU - GHS (H-Statements) Annex 6 Table 3-1
European Union / European Commission (EU EC)
Sensitizing Substance SP - Danger of photocontact sensitization
MAK
MAK Commission of Germany (Deutsche Forschungsgemeinschaft)
Skin sensitisation category 1
GHS - New Zealand
Te Mana Rauhī Taiao (New Zealand EPA)
H317 - May cause an allergic skin reaction [Skin sensitizer - Category 1]
GHS - Japan
Government of Japan
H317 - May cause an allergic skin reaction [Skin sensitization - Category 1]
GHS - Australia
Safe Work Australia
H317 - May cause an allergic skin reaction (unverified) [Skin sensitization - Category 1]
EU - Manufacturer REACH hazard submissions
European Union / European Commission (EU EC)

Direct Hazard » Other Health Effects

These sources refer directly to this chemical:

H335 - May cause respiratory irritation [Specific target organ toxicity - single exposure; Respiratory tract irritation - Category 3]
EU - GHS (H-Statements) Annex 6 Table 3-1
European Union / European Commission (EU EC)
H373 - May cause damage to organs through prolonged or repeated exposure [Specific target organs/systemic toxicity following repeated exposure - Category 2]
GHS - Japan
Government of Japan
H370 - Causes damage to organs [Specific target organs/systemic toxicity following single exposure - Category 1]
GHS - Japan
Government of Japan
H335 - May cause respiratory irritation [Specific target organ toxicity - single exposure; Respiratory tract irritation - Category 3]
GHS - Australia
Safe Work Australia
H335 - May cause respiratory irritation (unverified) [Specific target organ toxicity - single exposure; Respiratory tract irritation - Category 3]
EU - Manufacturer REACH hazard submissions
European Union / European Commission (EU EC)
H370 - Causes damage to organs (unverified) [Specific target organ toxicity - single exposure - Category 1]
EU - Manufacturer REACH hazard submissions
European Union / European Commission (EU EC)

Inherent HazardsData sources

Restricted List – This chemical is on a list from an authoritative body recommending that its use be avoided.

Data sources

Direct Hazard » Restricted List

These sources refer directly to this chemical:

EPA Chemical of Concern - Action Plan published
US EPA - PPT Chemical Action Plans
US Environmental Protection Agency (US EPA)
TSCA Work Plan chemical - Action Plan in development
US EPA - PPT Chemical Action Plans
US Environmental Protection Agency (US EPA)
Precautionary list of substances recommended for avoidance
P&W - Precautionary List
Perkins+Will (P+W)
Chemicals of high concern
SCHF - Hazardous 100
Safer Chemicals, Healthy Families (SCHF)
Candidate Chemical List
CA SCP - Candidate Chemicals
California Department of Toxic Substance Control (CA DTSC)
Red List substances to avoid in Living Building Challenge V3 projects
Living Building Challenge 3.0 - Red List of Materials & Chemicals (retiring December 31, 2024)
International Living Future Institute (ILFI)
Substances selected for RMOA or hazard assessment
EU - PACT-RMOA Substances
European Union / European Commission (EU EC)
V3 2014 Substance of Concern List
BIFMA - e3/level Annex B list of chemicals
Business and Institutional Furniture Manufacturers Association (BIFMA)
Bisphenols and Phthalates
GSPI - Six Classes Precautionary List
Green Science Policy Institute (GSPI)
Substances restricted under REACH
EU - REACH Annex XVII non-CMRs
European Union / European Commission (EU EC)
Ingredients that are Prohibited for Use in Cosmetic Products
Health Canada - Cosmetic Ingredient Hotlist
Health Canada
Priority Chemicals
ME DEP - Chemicals of High Concern and Priority Chemicals
Maine Department of Environmental Protection
Chemicals of High Concern
MDH - Chemicals of High Concern and Priority Chemicals
Minnesota Department of Public Health
Priority Chemicals
MDH - Chemicals of High Concern and Priority Chemicals
Minnesota Department of Public Health
Chemicals of High Concern to Children
WA DoE - Chemicals of High Concern to Children
Washington State Department of Ecology (WA DOE)
Annex II - Prohibited Substances
EU - Cosmetics Regulation
European Union / European Commission (EU EC)
Designated Chemical
CA DTSC - Biomonitoring California Chemical List
California Department of Toxic Substance Control (CA DTSC)
CoHC List (non SVHC)
CPA - Chemical Footprint
Clean Production Action (CPA)
Biological and Environmentally Released Materials
C2C Certified v4 Product Standard Restricted Substances List (RSL) - Effective July 1, 2022
Cradle to Cradle Products Innovation Institute (C2CPII)
Children's Products
C2C Certified v4 Product Standard Restricted Substances List (RSL) - Effective July 1, 2022
Cradle to Cradle Products Innovation Institute (C2CPII)
Formulated Consumer Products
C2C Certified v4 Product Standard Restricted Substances List (RSL) - Effective July 1, 2022
Cradle to Cradle Products Innovation Institute (C2CPII)
Red List substances to avoid in Living Building Challenge V3.1 projects
Living Building Challenge 3.1 - Red List of Materials & Chemicals (retiring December 31, 2024)
International Living Future Institute (ILFI)
Red List substances to avoid in Living Building Challenge V4.0 projects
Living Building Challenge 4.0 - Red List of Materials & Chemicals - Effective April 1, 2024
International Living Future Institute (ILFI)
2019 Substance of Concern List
BIFMA - e3/level Annex B list of chemicals
Business and Institutional Furniture Manufacturers Association (BIFMA)
Declarable and Reference Substance Lists (DSL and RSL)
IEC 62474 - Material Declaration for Products of and for the Electrotechnical Industry
International Electrotechnical Commission
Chemicals of High Concern to Children
Vermont Chemicals of High Concern to Children
Vermont Environmental Health Division
Reportable Chemicals
MA Toxics Use Reduction Act (TURA) listed substances
Massachusetts Department of Environmental Protection
Cosmetics & Personal Care Products
C2C Certified v4 Product Standard Restricted Substances List (RSL) - Effective July 1, 2022
Cradle to Cradle Products Innovation Institute (C2CPII)
Food Contact Chemicals Database Version 5.0
Food Contact Chemicals Database (FCCdb)
Food Packaging Forum
Food Contact Chemicals of Concern List (FCCoCL) - TIER 1
Food Contact Chemicals of Concern (FCCoCL)
Food Packaging Forum
Substances of Very High Concern (RIVM ZZS)
Substances of Very High Concern (RIVM ZZS)
The National Institute for Public Health and the Environment (RIVM)
Substances Restricted in Toys
The Toy Safety Directive
European Union / European Commission (EU EC)
Target Priority Chemicals List (TPCL)
Target Corp - Target Priority Chemicals List (TPCL)
Target Corporation
ZDHC - MRSL v2.0
ZDHC - MRSL v2.0
Zero Discharge of Hazardous Waste Chemicals Programme
EDF Key chemicals of concern in food packaging and food handling equipment
EDF Key chemicals of concern in food packaging and food handling equipment
Environmental Defense Fund
FSAP Food Packaging Product Stewardship Considerations
FSAP Food Packaging Product Stewardship Considerations
Food Safety Alliance for Packaging (FSAP)
FPF Priority Substance List from FCCdb
FPF Priority Substance List from FCCdb
Food Packaging Forum
Bisphenols
GreenScreen Certified Standard for Food Service Ware RSL
Clean Production Action (CPA)
Food Packaging Forum Priority Substances List
GreenScreen Certified Standard for Food Service Ware RSL
Clean Production Action (CPA)
TSCA Commercially Active
TSCA Chemical Substance Inventory (Active-Inactive)
US Environmental Protection Agency (US EPA)
Bisphenols
AFIRM Packaging RSL
The Apparel and Footwear International RSL Management Group (AFIRM)
Bisphenols (Bronze List)
GreenScreen Certified Standard for Furniture & Fabrics Bronze RSL
Clean Production Action (CPA)
Bisphenols (Silver-Gold)
GreenScreen Certified Standard for Furniture & Fabrics Silver-Gold RSL
Clean Production Action (CPA)
GADSL Declarable Substances - Reporting is required by a regulation (D/LR)
Global Automotive Declarable Substance List (GADSL)
Global Automotive Stakeholder Group (GASG)
Bisphenols (Silver-Gold)
GreenScreen Certified Standard for Medical Supplies & Devices Silver-Gold RSL
Clean Production Action (CPA)
GreenScreen LT-1 (based on 2018 Chemical Footprint Project)
GreenScreen Certified Standard for Medical Supplies & Devices Silver-Gold RSL
Clean Production Action (CPA)
Bisphenols (Bronze List)
GreenScreen Certified Standard for Medical Supplies & Devices Bronze RSL
Clean Production Action (CPA)
Potential CHRONIC health effects (over time or long-term)
OR OHA - High Priority Chemicals of Concern for Children's Health (HPCCCH)
Oregon Health Authority
Restricted Substances in Products
Apple Regulated Substances Specification
Apple Inc.
Reportable Substances and Future Restrictions in Products
Apple Regulated Substances Specification
Apple Inc.
DSL-all
EC - CEPA DSL
Environment Canada & Health Canada (EC)

How does this chemical impact the environment?Data sources

Immediate Harm To Aquatic Ecosystems, priority orange

Immediate Harm to Aquatic Ecosystems – A single exposure may result in severe biological harm or death to fish or other aquatic organisms.

Long-term Harm To Aquatic Ecosystems, priority orange

Long-Term Harm to Aquatic Ecosystems – Long term exposure may result in irreversible harm to fish or other aquatic organisms.

Bioaccumulative – Accumulates in organisms, concentrating as it moves up the food chain.

Persistent – Does not break down readily from natural processes.

Data sources

Direct Hazard » Immediate Harm to Aquatic Ecosystems

These sources refer directly to this chemical:

H400 - Very toxic to aquatic life [Hazardous to the aquatic environment (acute) - Category 1]
EU - GHS (H-Statements) Annex 6 Table 3-1
European Union / European Commission (EU EC)
H401 - Toxic to aquatic life [Hazardous to the aquatic environment (acute) - Category 2]
GHS - Japan
Government of Japan
H400 - Very toxic to aquatic life (unverified) [Hazardous to the aquatic environment (acute) - Category 1]
EU - Manufacturer REACH hazard submissions
European Union / European Commission (EU EC)
Hazardous to the aquatic environment - acute category 1
GHS - New Zealand
Te Mana Rauhī Taiao (New Zealand EPA)

Direct Hazard » Long-Term Harm to Aquatic Ecosystems

These sources refer directly to this chemical:

H410 - Very toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment (chronic) - Category 1]
EU - GHS (H-Statements) Annex 6 Table 3-1
European Union / European Commission (EU EC)
H411 - Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment (chronic) - Category 2]
GHS - Japan
Government of Japan
H412 - Harmful to aquatic life with long lasting effects (unverified) [Hazardous to the aquatic environment (chronic) - Category 3]
EU - Manufacturer REACH hazard submissions
European Union / European Commission (EU EC)
H410 - Very toxic to aquatic life with long lasting effects (unverified) [Hazardous to the aquatic environment (chronic) - Category 1]
EU - Manufacturer REACH hazard submissions
European Union / European Commission (EU EC)
H411 - Toxic to aquatic life with long lasting effects (unverified) [Hazardous to the aquatic environment (chronic) - Category 2]
EU - Manufacturer REACH hazard submissions
European Union / European Commission (EU EC)